The reference site for Tropisetron

Tropisetron (INN) is a serotonin 5-HT3 receptor antagonist used mainly as an antiemetic to treat nausea and vomiting following chemotherapy, although it has been used experimentally as an analgesic in cases of fibromyalgia.

WHAT IS Tropisetron?

Tropisetron is used to treat sickness caused by cancer chemotherapy or radiotherapy. It is also used to prevent and treat sickness that can sometimes occur after an operation.

This medicine is known as a 5-HT3 receptor blocker. Serotonin (5-HT) is a chemical produced by the nervous system. Specific receptors in the body bind with serotonin with different results. 5-HT3 receptors are present in the brain and gut.

Stimulation of these receptors by serotonin contributes to the sensation of nausea and the reflex action of vomiting. Tropisetron acts directly on 5-HT3 receptors in the gut to block serotonin thereby preventing nausea and vomiting. It is also thought to block 5-HT3 receptors in the brain, further preventing these symptoms.

 

Brand Name(s): Navoban
CAS nº: 105826-92-4

 

Product Info

The sections below will provide you with more specific information and guidelines related to tropisetron and its correct use. Please read them carefully.

FDA Information

Tropisetron is not currently available in the United States. However, this medicine is available in many countries such as  the UK, New Zeland and Australia.

Please visit the official site of the FDA for further information.

Why is this medication prescribed?

Tropisetron is used to treat sickness caused by cancer chemotherapy or radiotherapy. It is also used to prevent and treat sickness that can sometimes occur after an operation.

This medicine is known as a 5-HT3 receptor blocker. Serotonin (5-HT) is a chemical produced by the nervous system. Specific receptors in the body bind with serotonin with different results. 5-HT3 receptors are present in the brain and gut. Stimulation of these receptors by serotonin contributes to the sensation of nausea and the reflex action of vomiting.

Tropisetron acts directly on 5-HT3 receptors in the gut to block serotonin thereby preventing nausea and vomiting. It is also thought to block 5-HT3 receptors in the brain, further preventing these symptoms from developing.

Other uses for this medicine

European studies are suggesting tropisetron may also help patients with fibromyalgia, including reducing pain, dizziness, depression and improving sleep.

Nevertheless, no FDA approval has been given for these uses.

Dosage and using this medicine

Always take tropisetron exactly as directed by your doctor.

Tropisetron should be taken on an empty stomach. Your stomach is usually empty an hour before food or at least two hours after eating.

This medicine should start to work within one to two hours of taking a dose. If you are sick within one hour take the dose again.

If you are taking tropisetron to treat sickness caused by cancer chemotherapy or radiotherapy, a dose should be taken one to two hours before treatment and followed by another dose twelve hours later.

Never take more than the prescribed dose. If you suspect that you or someone else has taken an overdose of tropisetron contact your doctor or go to the accident and emergency department of your local hospital at once. Always take the container with you, if possible, even if it is empty.

This medicine is for personal use. Never give it to others even if their condition appears to be the same as yours.

What special precautions should I follow?

BEFORE TAKING TROPISETRON:

It is important that you tell your doctor if you have any of these health problems/medical conditions: kidney problems, liver problems, heart problems, or high blood pressure that is not controlled. Your doctor may want to take special precautions if you have any of these conditions.

Always inform your doctor if you have any allergies to: tropisetron, any other medicines, foods, dyes or preservatives. Your doctor will want to know if you are prone to allergies.

Furthermore, tell your doctor if you are taking any other medicines, including any that you buy without a prescription from a pharmacy, supermarket or health food shop.

Mixing some medicines and Navoban® (tropisetron) may interfere with each other. These include: rifampicin, phenobarbital, some medicines for your heart, any medicine that has caused problems with your heart rhythm since this effect could be worsened. You may need to take a different dosage or you may even require changing medication altogether.

Be careful driving, operating machinery or doing jobs that require you to be alert until you know how tropisteron affects you.

Navoban® may cause dizziness or tiredness in some people. If you have any of these symptoms, do not drive or do anything else that could be dangerous.

Do not use Navoban® if you are pregnant or intend to become pregnant or you are breast-feeding. There is not enough information on the use of this medicine in pregnancy. It is not known if Navoban® passes into breast milk and could affect your baby.

Do not use Navoban® if the packaging is torn or shows signs of tampering. If this is the case, return it to your pharmacist.

Do not give this medicine to a child. There is not enough information to recommend its use in children.

What should I do if I forget a dose?

If it is almost time for your next dose, skip the dose you missed and take the next dose when you are meant to. Otherwise, take it as soon as you remember, and then go back to taking it as you would normally.

Never take a double dose to make up for the one that you missed.

What side effects can this medication cause?

Possible side effects from tropisetron include:

headache
nausea
vomiting

Tell your doctor if any of these symptoms are severe or do not go away:

headache
constipation
dizziness
tiredness, sleepiness
stomach pain
diarrhoea
loss of appetite

If you experience any of the following symptoms, call your doctor immediately:

changes in your heart beat
fainting
skin rash or itching, sometimes with flushing of the face
tight feeling in the chest
wheezing or troubled breathing

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

What storage conditions are needed for this medicine?

Always keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).

Remember to throw away any medication that is outdated or no longer needed and, should it be necessary, talk to your pharmacist about the proper disposal of your medication.

In case of an emergency/overdose

Seek emergency medical attention if an overdose is suspected.

Symptoms of overdose may include:

visual hallucinations
high blood pressure

Product Images

PICTURES OF TROPISETRON PILLS

Below you will find images and specific information on the principal types of tropisetron that exist, including their respective brand name(s), strength, inscription codes, manufacturers and/or distributors.

The information below includes general information and guidelines for patients taking this medication and should never be used to substitute professional medical advice that can be provided by a qualified physician or family doctor.

Name: NAVOBAN®
Strength(s): 5 MG
Imprint: NAVOBAN 5mg
Manufacturer: NOVARTIS

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